Researchers at the University of Colorado School of Medicine managed to find a kind of a special molecule that can prevent the development of type 1 diabetes in mice, and have the same effect on human cells of diabetics.
Researchers hope these findings into new hope in the fight against diabetes, especially type I, while also other autoimmune disorders such as rheumatoid arthritis (RA), multiple sclerosis and celiac (inflammation of the small intestine). The findings are published in the latest issue of The Journal of Immunology.
“We found that when you place a certain molecules into specific structural pockets, it will be able to inhibit the formation of diabetes,” said George Eisenbarth, MD, Ph.D., executive director of the Barbara Davis Center in collaboration with Aaron Michels, MD, assistant professor from the University of Colorado School of Medicine.
Researchers are looking for small molecules capable of filling the pockets along the groove binding proteins. Several molecules are known to go into the pockets and inhibit the presentation of insulin to enhance cell immunity.
As is known, type I diabetes is a condition where the body is unable to produce insulin because the pancreas is not functioning due to damaged immune system itself (autoimmune).
Michels and Eisenbarth Glyphosine found that compounds able to improve the presentation of insulin and prevent diabetes in mice. This has the same effect on human cells. In fact according to them, the mice can remain free of diabetes during receiving daily injections of the compound. However, in mice that already have diabetes, it would not be useful.
“This technique will also apply to other autoimmune disorders such as arthritis and celiac disease,” said Michels.
He added, for the next step will be experiments specifically on human cells and develop a new therapy to be used clinically. This at least will materialize within the next five years.Source of EurekAlert